See Inside Living Cells in Greater Detail Using New Microscopy Technique

Experts in optical physics have developed a new way to see inside living cells in greater detail using existing microscopy technology and without needing to add stains or fluorescent dyes. Since individual cells are almost translucent, microscope cameras must detect extremely subtle differences in the light passing through parts of the cell. Those differences are known as the phase of the light. Camera image sensors are limited by what amount of light phase difference they can detect, referred to as dynamic range. “To see greater detail using the same image sensor, we must expand the dynamic range so that we can detect smaller phase changes of light,” said Associate Professor Takuro Ideguchi from the University of Tokyo Institute for Photon Science and Technology. The research team developed a technique to…
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